I have dual US/other citizenship. US tax filings are much more complicated and scarier from overseas (I do my own, as I did when I lived in the US, but the law is much murkier when you're an expat, so it's harder to be sure what you should do, the penalties for getting it wrong are terrifying, and a lot of things are "objectively" murky, meaning that tax professionals won't be able to be sure what to do either).
Lots of people will advise you to use the earned income exclusion to avoid double taxation. This is the quick and simple way to deal to wage income earned overseas - and that certainly does simplify some aspects of filing - but if you're going to be living some place with higher taxes than the US, and particularly if you plan on drawing some passive income at some point, it can be worth looking into whether the simple approach is the best one (for me, it isn't - I use foreign tax credits to avoid double taxation - ymmv). It's also worth looking very, very closely at how US tax law treats retirement vehicles wherever you settle - this can be a surprisingly murky area, and you may not be able to avoid being in a murky situation, depending on whether the country you are moving to has any compulsory retirement funding provisions...
You should also be aware that informational reporting becomes much more intrusive once you open overseas accounts - make sure you're aware of things you need to file that are not part of a standard tax return, and that wouldn't be required if you were resident in the US. Again, the penalties can get really scary here if you do the wrong thing, even though the "right" thing isn't always particularly clear...
All of this is perfectly doable - it's just a pita and sort of provides an annual insinuation that, if you've moved overseas, the US government regards you as likely to be engaged in some sort of criminal activity...