Everybody here seems to be praising where they are from/living and pushing for that area. I thought I saw Detroit on here. Here is what Wikipedia says about Detroit and when it peaked as a place to live:
Detroit reached its population peak in the 1950 census at over 1.8 million people, and decreased in population with each subsequent census; as of the 2010 census, the city has just over 700,000 residents, adding up to a total loss of 61% of the population.
Since Cincinnati is high on your list I thought I would opine here. I live in Cincinnati (13 years now) but am not originally from here so I am giving you outsider's perspective with no real emotional attachment to the place. I would move out West in a heartbeat. My problem is I am too invested here (some real estate investments, career in which I make too much money and I don't mind the work), and my kids are in schools they love while my wife likes our community and our house. I don't particularly. Vast majority of people here are hard core conservatives and I don't see eye to eye with them. The nature and active things to do are non-existent. Nearest lake is 3-4 hours away (almost too far away for a weekend), beach is 12+ hours away and no real mountains to speak of. Biking infrastructure is pretty terrible. If I want to go skiing, which I love, I always end up spending the $ and going to Colorado as the closest reasonable option since WV and Northeast do not fit the bill when I consider possibility of no snow, cost, distance. Don't get me started on "professional sports". Delta has abandoned Cincinnati as a hub so the large airport is mostly empty, there is only 1 direct connection to Europe remaining and direct connections within U.S. are harder to come by. And yet it stays near the top or at the top of the "most expensive airports to fly out of in the U.S." I've thought many times of moving to Denver, but I would have to take a 60-70% pay cut and the cost of living/real estate is double of what it is here so at this point it is a no go. As I've just discovered and converted to mustachianism beginning of 2015, I have a long way to go and have accepted this as the place where I will stay at least until my kids go to college. I will push them out West for school and we can hopefully join them at that point in time.
Think of it this way, where you are located now a house you want costs $1m. Here it is $500k or possibly less. There is a good reason for that. Unless you just have a completely different set of preferences than I do and you would fit in with what I described, then absolutely go for it.
It is not all bad, there are good things about Cincinnati, especially if you like baseball. I don't. Affordability, decent schools - especially if you are into private Catholic schools. I am not, so my kids go to a decent public school. There are plenty of Fortune 500 companies to work for and with the economy humming along and auto industry doing as well as they are, jobs seem plentiful. Anyway, this is getting too long and I realize I am complaining way too much (haven't yet finished the Stoicism book obviously). But I will be shocked if I retire here in hopefully ~10 years. And the climate in the Ohio River valley is a hotbed of allergy development with too many humid days for my taste! ;) Good luck.