I'm a retired FSO (Foreign Service Officer) who actually adjudicated visas in Caracas back in the day (25 years ago). Applicants for a tourist visa need to show that the ties they have to their native countries are strong enough to impel them to return (i.e., not stay in the U.S. as an undocumented worker). Due to Venezuela's economic and political situation, your friend is going to have his work cut out for him. Having strong family ties is a good start, but many parents leave their kids for years on end in order to get a job and send money back. Working in a job that one has had for a few years (shows stability) is also good, but depending on the salary this might not be a significant factor. One thing that might factor in positively is whether your friend has a history of traveling to other countries (and can prove it via the stamps in his passport) and then returning in accordance with the restrictions set by those visas. Of course if your friend has spent 52 of the last 60 months touring around Curacao, Brazil and Argentina, this just might backfire.
Good luck.