OP, it's good to think about new vs used, and as you can see the MMM community generally (strongly) favors used. To give a story on the other side, I bought a car last month, and carefully considered new vs used. We went new, partially because my partner felt more secure that way, but also in large part because for the car we wanted we found adding 4 years and 30000 miles to it only saved two or three thousand dollars, which didn't seem worth it.
Up-front cost is certainly a huge factor (ie: would you be just as happy with a 20K new car?), but as far as depreciation, I think it's key to look at MMM's most recent post about net worth:
Don’t bother with depreciating consumer stuff like your cars, furniture, or Apple products, unless you are willing to sell them right now.
If you're going to drive it into the ground, forget about depreciation. Just make sure you're not overspending your needs in up-front costs. It's a different story if you plan to sell it in five years, of course.
As for your actual original question, I'm afraid I don't know a lot about bonds, but if you can afford to invest long term, even a more volatile equities index fund should come out ahead in the long run. I wouldn't carry too much debt but a little low interest stuff probably isn't a bad idea if it's to invest the rest.