I'll be one of the few to admit in the comments that I still drive. It's over 20 miles away, and I leave work at 10:30pm when I'm lucky, sometimes as late as 2 am. I could take a combo of buses to work, but not home because they stop running. Biking - it's possible, but 1) I'm physically tired at the end of a shift as it is and 2) The idea of biking beside the highway at midnight scares the crap out of me, especially with the fog and rain we get.
I'm working on what I think is the best option - find a new job at the hospital that's less than a mile from my house. I could bike or walk through quiet residential neighborhoods, taking barely more time than driving, especially once you factor in finding parking. I walked/biked for 5 years at a previous job and loved it. No traffic, and it takes a consistent amount of time to get to/from work.