A collection of miscellaneous thoughts:
1. I did not go to a friend's wedding in Brooklyn for financial reasons, and it still is probably one of my top regrets in life. I get upset every time I see him knowing I missed his wedding. Your reasoning for missing your friend's wedding would be different, but it's possible you might feel the same.
2. If you are generally concerned about COVID, driving seems less safe than flying. I've done a 26 hour road trip before and that means stopping 6 or 7 times at 1-2 places each time. That's 4-5 gas stations, 4-5 restaurants, a hotel (or two), etc. It just doesn't seem safer than flying to me.
3. I really, really, really don't want to get into a COVID debate, but your options presented indicate to me that you don't have a rational view of what's going on right now, who the virus is affecting, etc. The data is coming in and we now know that the majority of deaths -- in many states more than 70% -- are nursing homes deaths, and that's even with governors blatantly covering up their malpractice nursing home policies. I'm not going to argue about COVID, but just look at the CDC data and stop watching the news (seriously, best decision I made during this was cancelling YouTubeTV).
Data is here --
https://data.cdc.gov/NCHS/Provisional-COVID-19-Death-Counts-by-Sex-Age-and-S/9bhg-hckuThe data admittedly lags, but 34 and under (I'm assuming your age group) has had a TOTAL of 780 COVID deaths. You AND YOUR KIDS are fine man. Take a breath.
4. I too have a toddler (15 month old), and if this were me, I would go to the wedding, act responsibly, monitor symptoms when I got home, and go from there.