Nobody has said it, but property tax rates! There was a town I thought I really wanted to live in, but property taxes were about 1/3 higher than where I ended up. (In NJ, property taxes are almost half of my monthly mortgage payment.)
I looked at my current town a lot on real estate listings, and on my lunch hour I would go drive by all the listings. I thought I wanted a condo, but I didn't like the condo communities in my price range. Some neighborhoods in my town looked alright online, but when I drove through them, I changed my mind. I liked the neighborhood next to my current neighborhood when I drove around, so I focused my search there. I also used city-data.com to find out which pockets had the highest income to make sure I was in the right area.
My house is close to a major university (10-15 minute drive) and a few international company headquarters, so I know I'll be able to sell it quickly. There are plenty of jobs in my area- lots of industry and close to highways. The school system is meh, but I don't plan to have kids.
When I bought my first home (townhouse), it was in a rural town not particularly close to anything. It was a one-bedroom unit. It was hard to sell because of the layout and location. I had erroneously thought I could rent it, but nobody wanted to live in that town.
If you can talk to people who are leaving the area or moving to the area- find out WHY they are leaving or moving in. I know someone leaving my current town because there are now too many Indian people for her liking. That is not a problem in my eyes.