1) Shooting for beyond 95% success rate in cFiresim. That alone should be a huge safety factor.
2) Planning for annual retirement spending that is about $5k more than current after-tax spending. This should allow for the occasional vacation, car replacement, medical event, or other unexpected expense.
3) Not factoring in an inheritance that I'm likely to receive at some point. I have no idea on the amount or timing, so I figure it's best to just ignore it.
Other than that, I'm being pretty aggressive compared to most folks. I'm counting on SS and a small pension, even though a lot can happen in the 15 or so years until I'm eligible to draw on those. I'm assuming the ACA will allow me to get health insurance roughly equivalent to my current employer-subsidized plan. I'm factoring in the fact that my house will be paid off in 12 years, and spending will drop accordingly.
Plan B: part-time or consulting work if projected success rate drops below 80-85%.