Okay boys and girls, hold on to your socks. Here is my
OPINION of which primary sources would be highly relevant to the Internet
Retirement Diet Police. Demonstrating the mechanisms that link saturated fat, excess dietary fat to obesity and diabetes.
Also attached another 127 references from Dr Greger's book. (This is just for the chapter on Diabetes. The full list of references is about 80 pages).
Please don't make me do the same thing for cholesterol and heart disease - much easier just to send everyone on over to nutritionfacts.org
Cheers!
RPG
R L Westley, F E May. A twenty-first century cancer epidemic caused by obesity: the involvement of insulin, diabetes, and insulin-like growth factors. Int J Endocrinol. 2013;2013:632461
http://www.ncbi.nlm.nih.gov/pubmed/23983688Diabetes Care. Standards of Medical Care in Diabetes—2014. American Diabetes Association.
http://care.diabetesjournals.org/content/37/Supplement_1/S14.extractR Taylor. Banting Memorial lecture 2012: reversing the twin cycles of type 2 diabetes. Diabet Med. 2013 Mar;30(3):267-75.
http://www.ncbi.nlm.nih.gov/pubmed/23075228R Taylor. Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause. Diabetologia. 2008 Oct;51(10):1781-9.
http://www.ncbi.nlm.nih.gov/pubmed/18726585A H Lichtenstein, U S Schwab. Relationship of dietary fat to glucose metabolism. Atherosclerosis. 2000 Jun;150(2):227-43.
http://www.ncbi.nlm.nih.gov/pubmed/10856515E W Kraegen, G J Cooney. Free fatty acids and skeletal muscle insulin resistance. Curr Opin Lipidol. 2008 Jun;19(3):235-41.
http://www.ncbi.nlm.nih.gov/pubmed/18460913L M Sparks. H Xie, R A Koza, R Mynatt, M W Hulver, G A Bray, S R Smith. A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. Diabetes. 2005 Jul;54(7):1926-33.
http://www.ncbi.nlm.nih.gov/pubmed/15983191W J Evans. Oxygen-carrying proteins in meat and risk of diabetes mellitus. JAMA Intern Med. 2013 Jul 22;173(14):1335-6.
http://www.ncbi.nlm.nih.gov/pubmed/23778318D Estadella, C M da Penha Oller do Nascimento, L M Oyama, E B Ribeiro, A R Damaso, A de Piano. Lipotoxicity: effects of dietary saturated and transfatty acids. Mediators Inflamm. 2013; Epub 2013 Jan 31.
http://www.ncbi.nlm.nih.gov/pubmed/23509418L M Goff, J D Bell, P W So, A Dornhorst, G S Frost. Veganism and its relationship with insulin resistance and intramyocellular lipid. Eur J Clin Nutr. 2005 Feb;59(2):291-8.
http://www.ncbi.nlm.nih.gov/pubmed/15523486G Perseghin, P Scifo, F De Cobelli, E Pagliato, A Battezzati, C Arcelloni, A Vanzulli, G Testolin, G Pozza, A Del Maschio, L Luzi. Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes. 1999 Aug;48(8):1600-6.
http://www.ncbi.nlm.nih.gov/pubmed/10426379B Vessby, M Uusitupa, K Hermansen, G Riccardi, AA Rivellese, L C Tapsell, C Nalsen, L Berglund, A Louheranta, B M Rasmussen, G D Calvert, A Maffetone, E Pedersen, I B Gustafsson, L H Storlien, KANWU Study. Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study. Diabetologia. 2001 Mar;44(3):312-9.
http://www.ncbi.nlm.nih.gov/pubmed/11317662J Gojda, J Patkova, M Jacek, J Potockova, J Trnka, P Kraml, M Andel. Higher insulin sensitivity in vegans is not associated with higher mitochondrial density. Eur J Clin Nutr. 2013 Dec;67(12):1310-5.
http://www.ncbi.nlm.nih.gov/pubmed/24149445C J Nolan, C Z Larter. Lipotoxicity: why do saturated fatty acids cause and monounsaturates protect against it? J Gastroenterol Hepatol. 2009 May;24(5):703-6.
http://www.ncbi.nlm.nih.gov/pubmed/19646010J Ye. Role of insulin in the pathogenesis of free fatty acid-induced insulin resistance in skeletal muscle. Endocr Metab Immune Disord Drug Targets. 2007 Mar;7(1):65-74.
http://www.ncbi.nlm.nih.gov/pubmed/17346204E W Kraegen, G J Cooney. Free fatty acids and skeletal muscle insulin resistance. Curr Opin Lipidol. 2008 Jun;19(3):235-41.
http://www.ncbi.nlm.nih.gov/pubmed/18460913V T Samuel, G I Shulman. Mechanisms for insulin resistance: common threads and missing links. Cell. 2012 Mar 2;148(5):852-71.
http://www.ncbi.nlm.nih.gov/pubmed/22385956A R Martins, R T Nachbar, R Gorjao, M A Vinolo, W T Festuccia, R H Lambertucci, M F Cury-Boaventura, L R Silveira, R Curi, S M Hirabara. Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function. Lipids Health Dis. 2012 Feb 23;11:30.
http://www.ncbi.nlm.nih.gov/pubmed/22360800H Karlic, D Schuster, F Varga, G Klindert, A Lapin, A Haslberger, M Handschur. Vegetarian diet affects genes of oxidative metabolism and collagen synthesis. Ann Nutr Metab. 2008;53(1):29-32.
http://www.ncbi.nlm.nih.gov/pubmed/18772587 K L Spalding, E Arner, P O Westermark, S Bernard, B A Bucholz, O Bergmann, L Blomgvist, J Hoffstedt, E Naslund, T Britton, H Concha, M Hassan, M Ryden, J Frisen, P Arner. Dynamics of fat cell turnover in humans. Nature. 2008 Jun 5;453(7196):783-7.
http://www.ncbi.nlm.nih.gov/pubmed/18454136J S Pankow, B B Duncan, M I Schmidt, C M Ballantyne, D J Couper, R C Hoogeveen, S H Golden: Athersclerosis Risk in Communities Study. Fasting plasma free fatty acids and risk of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes Care. 2004 Jan;27(1):77-82.
http://www.ncbi.nlm.nih.gov/pubmed/14693970O P Bachmann, D B Dahl K Brechtel, J Machann, M Happ, T Maier, M Loviscach, M Stumvoll, C D Claussen, F Schick, H U Haring, S Jacob. Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans. Diabetes. 2001 Nov;50(11):2579-84.
http://www.ncbi.nlm.nih.gov/pubmed/11679437S Hocking, D Samocha-Bonet, K L Milner, J R Greenfield, D J Chisholm. Adiposity and Insulin Resistance in Humans: The Role of the Different Tissue and Cellular Lipid Depots. Endocr Rev. 2013 Aug;34(4):463-500.
http://www.ncbi.nlm.nih.gov/pubmed/23550081J Ye. Role of insulin in the pathogenesis of free fatty acid-induced insulin resistance in skeletal muscle. Endocr Metab Immune Disord Drug Targets. 2007 Mar;7(1):65-74.
http://www.ncbi.nlm.nih.gov/pubmed/17346204E W Kraegen, G J Cooney. Free fatty acids and skeletal muscle insulin resistance. Curr Opin Lipidol. 2008 Jun;19(3):235-41.
http://www.ncbi.nlm.nih.gov/pubmed/18460913M Roden. How free fatty acids inhibit glucose utilization in human skeletal muscle. News Physiol Sci. 2004 Jun;19:92-6.
http://www.ncbi.nlm.nih.gov/pubmed/15143200H P Himsworth. The dietetic factor determining the glucose tolerance and senility to insulin of healthy men. Clinical Science 2, 67-94.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1394223/H P Himsworth, E M Marshall. The diet of diabetics prior to the onset of the disease. Clinical Science 2, 95-115, 1935. NA.
https://www.cabdirect.org/cabdirect/abstract/19351404498M Roden, T B Price, G Perseghin, K F Petersen, D L Rothman, G W Cline, G I Shulman. Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest. Jun 15, 1996; 97(12): 2859–2865.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC507380/S Lee, C Boesch, J L Kuk, S Arsianian. Effects of an overnight intravenous lipid infusion on intramyocellular lipid content and insulin sensitivity in African-American versus Caucasian adolescents. Metabolism. 2013 Mar;62(3):417-23.
http://www.ncbi.nlm.nih.gov/pubmed/23122836M Roden, K Krssak, H Stingl, S Gruber, A Hofer, C Furnsinn, E Moser, W Waldhausl. Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans.
http://www.ncbi.nlm.nih.gov/pubmed/10334314M Krssak, K Falk Petersen, A Dresner, L Dipetro, S M Vogel, D L Rothman, M Roden, G I Shulman. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia. 1999 Jan;42(1):113-6.
http://www.ncbi.nlm.nih.gov/pubmed/10027589J Shirley Sweeney. DIETARY FACTORS THAT INFLUENCE THE DEXTROSE TOLERANCE TEST A PRELIMINARY STUDY. JAMA Int Med, Dec, 1927, Vol 40, No. 6.
http://archinte.jamanetwork.com/article.aspx?articleid=535594E W Kraegen, G J Cooney. Free fatty acids and skeletal muscle insulin resistance. Curr Opin Lipidol. 2008 Jun;19(3):235-41.
http://www.ncbi.nlm.nih.gov/pubmed/18460913A T Santomauro, G Boden, M E Silva, D M Rocha, FR F Santos, M J Ursich, P G Strassmann, B L Wajchenberg. Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects. Diabetes. 1999 Sep;48(9):1836-41.
http://www.ncbi.nlm.nih.gov/pubmed/0010480616W J Evans. Oxygen-carrying proteins in meat and risk of diabetes mellitus. JAMA Intern Med. 2013 Jul 22;173(14):1335-6. doi: 10.1001/jamainternmed.2013.7399.
http://www.ncbi.nlm.nih.gov/pubmed/23778318M Cnop. Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes. Biochem Soc Trans. 2008 Jun;36(Pt 3):348-52. doi: 10.1042/BST0360348.
http://www.ncbi.nlm.nih.gov/pubmed/18481955R Taylor. Banting Memorial lecture 2012: reversing the twin cycles of type 2 diabetes. Diabet Med. 2013 Mar;30(3):267-75. doi: 10.1111/dme.12039.
http://www.ncbi.nlm.nih.gov/pubmed/23075228A K Leamy, R A Egnatchik, J D Young. Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease. Prog Lipid Res. 2013 Jan;52(1):165-74. doi: 10.1016/j.plipres.2012.10.004.
http://www.ncbi.nlm.nih.gov/pubmed/23178552D Estadella, C M da Penha Oller do Nascimento, L M Oyama, E B Ribeiro, A R Dâmaso, A de Piano. Lipotoxicity: effects of dietary saturated and transfatty acids. Mediators Inflamm. 2013;2013:137579. doi: 10.1155/2013/137579.
http://www.ncbi.nlm.nih.gov/pubmed/23509418R Taylor. Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause. Diabetologia. 2008 Oct;51(10):1781-9. doi: 10.1007/s00125-008-1116-7.
http://www.ncbi.nlm.nih.gov/pubmed/18726585D A Cunha, M Igoillo-Esteve, E N Gurzov, C M Germano, N Naamane, I Marhfour, M Fukaya, J M Vanderwinden, C Gysemans, C Mathieu, L Marselli, P Marchetti, H P Harding, D Ron, D L Eizirik, M Cnop. Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis. Diabetes. 2012 Nov;61(11):2763-75. doi: 10.2337/db12-0123.
http://www.ncbi.nlm.nih.gov/pubmed/22773666G Musso, R Gambino, F De Michieli, M Cassader, M Rizzetto, M Durazzo, E Fagà, B Silli, G Pagano. Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis. Hepatology. 2003 Apr;37(4):909-16.
http://www.ncbi.nlm.nih.gov/pubmed/12668986J Cao, X X Feng, L Yao, B Ning, Z X Yang, D L Fang, W Shen. Saturated free fatty acid sodium palmitate-induced lipoapoptosis by targeting glycogen synthase kinase-3β activation in human liver cells. Dig Dis Sci. 2014 Feb;59(2):346-57. doi: 10.1007/s10620-013-2896-2.
http://www.ncbi.nlm.nih.gov/pubmed/24132507C Xiao, A Giacca, A Carpentier, G F Lewis. Differential effects of monounsaturated, polyunsaturated and saturated fat ingestion on glucose-stimulated insulin secretion, sensitivity and clearance in overweight and obese, non-diabetic humans. Diabetologia. 2006 Jun;49(6):1371-9.
http://www.ncbi.nlm.nih.gov/pubmed/16596361M Cnop, S J Hughes, M Igoillo-Esteve, M B Hoppa, F Sayyed, L van de Laar, J H Gunter, E J de Koning, G V Walls, D W Gray, P R Johnson, B C Hansen, J F Morris, M Pipeleers-Marichal, I Cnop, A Clark. The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation. Diabetologia. 2010 Feb;53(2):321-30. doi: 10.1007/s00125-009-1562-x.
http://www.ncbi.nlm.nih.gov/pubmed/19855953M Ricchi, M R Odoardi, L Carulli, C Anzivino, S Ballestri, A Pinetti, L I Fantoni, F Marra, M Bertolotti, S Banni, A Lonardo, N Carulli, P Loria. Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. J Gastroenterol Hepatol. 2009 May;24(5):830-40. doi: 10.1111/j.1440-1746.2008.05733.x.
http://www.ncbi.nlm.nih.gov/pubmed/19207680C J Nolan, C Z Larter. Lipotoxicity: why do saturated fatty acids cause and monounsaturates protect against it? J Gastroenterol Hepatol. 2009 May;24(5):703-6. doi: 10.1111/j.1440-1746.2009.05823.x.
http://www.ncbi.nlm.nih.gov/pubmed/19646010D R Parker, S T Weiss, R Troisi, P A Cassano, P S Vokonas, L Landsberg. Relationship of dietary saturated fatty acids and body habitus to serum insulin concentrations: the Normative Aging Study. Am J Clin Nutr. 1993 Aug;58(2):129-36.
http://www.ncbi.nlm.nih.gov/pubmed/8338037D J Maron, J M Fair, W L Haskell. Saturated fat intake and insulin resistance in men with coronary artery disease. The Stanford Coronary Risk Intervention Project Investigators and Staff. Circulation. 1991 Nov;84(5):2020-7.
http://www.ncbi.nlm.nih.gov/pubmed/1934376L Wang, A R Folsom, Z J Zheng, J S Pankow, J H Eckfeldt, ARIC Study Investigators. Plasma fatty acid composition and incidence of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Clin Nutr. 2003 Jul;78(1):91-8.
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