Depends on what you are hoping to do.
It is easy for people to move later in life from say the NE with a high cost of living to the SE with a low cost of living. A lot of their cake is baked in terms of home equity having accrued nicely, social security payments being as robust as they can be, etc.
Moving from the SE to the NE can be, on the other hand, a bit more challenging. At least in my sector, rarely do the increased wages equal the COL differential and you see your money will go further in the SE.
However, some people, due to their values, might be comfortable being retired in the SE, but not actively working, and/or raising kids in the SE due to the schools, political climate, etc. Or, they might not be comfortable living in a more remote location for whatever reason. So then it becomes a “values” and “lifestyle” equation.
I have yet to find a better place to live economically than Florida or Nevada, but those places might not be for everyone. Also, as they have been booming, the value is decreasing, especially for young people starting out.