I think in the end it comes down to what really matters most to you, and what you want to get out of life. I am profoundly unhappy in my high-paying job, so much so that when it dawned upon me a few months ago that the money had pretty much become the main motivator for me getting up and going there every day, I decided to give my notice. I gave notice even though I'm one of those people like you mentioned in your OP who's not quite all the way there to FI yet. I gave notice almost a month ago now, and I would have left that very day if I could have; instead, my boss tried to bully me into staying longer because, let's face it, I'm not the only one who is so miserable working there, and they're perennially short-staffed. I'm just the one who's in good enough financial shape to be able to walk away from a job like that and go do something else that pays less but will hopefully be more enjoyable (which is what I'm doing).
To my mind, there is nothing money can buy me in this world that is more valuable than my time. I can always go out and earn more money if the need arises (even in my current field), but I cannot go out and manufacture more lifespan. Time is the most valuable commodity any of us can ever hope to earn or possess. Yet how often do we treat it indifferently because we don't have to actually do anything to "earn" it, in the sense that we just wake up every day and have a whole day's worth of it to "spend"? When you love what you're doing, time will fly, but when you hate it, then every moment is a drag on your psyche. Well, I found myself walking to work one day, saying to myself, "life is too short to be spending it at XYZ" (where XYZ is my current place of employment). And realizing that I really meant it. And that was when I started planning my exit. I literally can't think of anything else (from OP's list or otherwise) that will do more to enhance my joy for life and sense of purpose, than to leave this job. Even if it's not the best decision for my bottom line.