Our situation:
We were both 20 minutes or less from our offices... but have been fully remote since 2020.
My in-laws were 20 minutes away but last year they moved ~2 hours away, opposite direction of my family.
I had a few friends in the area, and she had some friends relatively close but again, opposite direction of my family.
Our area was higher cost of living in comparison. We were hoping to go cheaper on a house. It didn't exactly work out that way, but you still have a chance! (Editor's Note: Lifestyle inflation. We got a bigger, much newer house with central air, much bigger garage, more land, more privacy, higher ceilings, fully renovated, and a few other perks like whole house generator, hot tub, pellet stove, 6 networked security cameras, blah, blah but were able to sell the old house for just as much because of the HCOLA it's in.)
Anyway, we sold there, and bought here, and it was about a wash in home prices, but now we have a higher interest rate! (3->6%).
I have a lot of old friends in this area, but most I have not seen in ~10+ years and it has been a little hard to really reconnect, but we've only been here 3.5 months. I think when our new puppy is ready, we'll have more hosted events, smaller at first, and get some friends to crawl out of the woodwork. For now I have been missing friends a bit.
But... we're ~25 minutes from 2 close family members, 45-55 to 2 others, and also much closer to the extended family (cousins) on my side. So we're seeing way more family now!
We still have our jobs - but we're still in an area where I think we could both find work if we couldn't find something remote, but really needed to.
The bottom line, I think, is that it's hard to weigh friends "vs" family because that can be different for everyone. Where we lived, I did not feel like my friends were absolutely my people. I mean, some of them are, but I just about never saw them anyway. I'm not sure I'll find "my people" among my old friends either. But my family - I'm definitely making an effort to see them during our oh too short lives.
We also alternate (if unevenly) between making the long drive to see the in-laws or for them to come see us. We see them every 1-2 months for a long weekend. Not much different than before we moved. Also note that we just got a puppy. We were unfortunately unable to conceive children. So they did not factor into the decision for us. Nor did schools.