In my low-cost area, it's hard to justify fixer-uppers. The end price you get is usually at or less than what it takes to fix them up.
I bought a 1200sf at auction for $4300 back in 2004. After 5 years of DIY replumb, rewire, rewall, refloor, siding, windows, and HVAC, I sold it for $53k, a $20k gross profit. HOWEVER, that 20k is what I earned for 5 years of weekend labor. In other words, for dealing with asbestos, roaches, and a toilet that had mysterious barnacles on it, I made less than if I had taken a weekend shift at McDonalds. It was a disasterous move, based on me underestimating the time that kind of project takes, especially for a non-professional.
Worse, it delayed my decision to get a master's degree, after which my earnings finally took off.
Now if I lived in L.A. and bought a crack house for $430k, I could just pay $100k to have it fixed and still sell for a $100k profit.