You will need to be a lot more specific.
What kind of weather do you like?
What's your housing/COL budget?
What kind of politics do you like?
How big of a "city" do you mean?
How old are your kids and what do THEY like?
Do you like outdoor/indoor sports, museums/arts/culture, etc? If so, how would you prioritize?
Do you value proximity to family? If so, where do they live?
Do you want to be near an international airport?
I could go on and on. Don't get me wrong - you'll get lots of answers. But they will be from people who live where *they* like to live, which might be the opposite of where you want to live.
-W