I mostly give money to charities. I haven't itemized since we closed our mortgage, so it's not for a tax deduction.
Outside of family, there is one particular instance we significantly supported someone else. It was a high-drama family, with 3 kids, in another state. Very loving, but very out of the ordinary. (2 of the 3 kids were LGBTQ, and when we met them, they lived in a small town. One was suicidal for the experience) We came to find out, some years after we got to know them, that the father had a run-in with the law. He protested his innocence, and I believe to this day is was innocent, but he didn't handle the initial arrest particularly well, so the local prosecutor, who had political ambitions, seemed to want to make an example of him. (He was not violent--would never hurt a fly. But he was so disoriented that he did not unambiguously protest his innocence.)
We went up to visit them for a while, and watch their kids while they dealt with legal issues. They had nothing, so were relying on the Public Defender's office for representation. After seeing their family, still loving and caring through this high point of drama, I did a little research. See, the father's custody of the kids was at stake. And the win rate for the public defender's office was 60%. That night, I literally couldn't sleep thinking that he (or they) could lose contact with their kids on not much better than a coin toss. That, knowing that the prosecutor was going all out--bending rules to the point of breaking.
I just couldn't stand it. So, the next day I asked DW, and we told them we would pay for the defense. Let the facts be what they may, but they deserved a fair shake. They picked a lawyer they were comfortable with, and although I also vetted them, I had no further input to the case; just paid the invoices.
Long story short, the ambitious prosecutor lost. (though never disciplined, I think) Kids are now in their 20's and happily as weird as ever, talking about their future lives.
About the most direct impact I've ever had in a non-relative's life that I can think of.