Assuming you can handle the kids on your own, in your shoes I might send your DH (he's the sibling, right) and keep everyone else home. I do think that passing up a sibling's wedding is a huge deal, and although people rightfully gripe about destination weddings, once you get to a point where a lot of people have to travel and get hotel rooms anyway, I think it's less of an issue where they're going. (In fact, depending where you live, the destination might be easier to get to than the actual hometown.) Or would be it be possible to stay less than the full week? Then maybe it would be easier to get someone to stay with your kids and you could go too.