I've been through airport security several times with multiple computers. During on series of flights (involving two passes through security), between DH and I we had 4 laptops (only 2 of which worked, which was a bit concerning for me, but they didn't ask us to turn them on, thankfully), 2 ipads, an external hard drive, a zillion cords, a small set of speakers, and probably more.
We were taken aside and that bag was given extra scrutiny. I'm sure the tangle or wires and electronics looked... interesting. It was a pain because everything was very carefully Tetris-ed in that bag to make it fit. But other than an extra 10 or so minutes in security for the inspection and the repack, it was fine. This was in an Airport in Germany, and then again in the US after passing through customs during out layover.