Fun topic, I hope. We need some black humour these days, eh?
Take an acronym and rename it to something that refutes the original. They don't have to be political, although that might be the easiest, and most fun. Like limericks, the best will have some bite.
I'll start - these are not mine, but I do appreciate them:
PETA - People for the Eating of Tasty Animals. From People for the Ethical Treatment of Animals (note this is a very suspect organization)
MAGA - Make America Go Away. From, I'm sure almost all of us know this, Make America Great Again.
Edit - some of the acronyms people are starting from are more obscure, so let's put the original (or most common) after our version. I've edited mine.
BTW, I am impressed with how creative people are being!