As someone who has lived through some pretty epic struggles, I completely disagree with that comic. I enjoy the fact that my life is so comfortable and cushy now. I've already had enough struggle to last a lifetime. In my experience, being comfortable is exactly the same thing as being happy. The reason I've embraced Mustachianism is because I want to be comfortable and happy for the rest of my life.
The trick is that most "creature comforts" (like Starbucks lattes, luxury cars, tropical vacations, 4K TV sets, etc.) actually generate stress in people's lives because they borrow to finance these comforts and they end up working jobs they hate to make their loan payments. People need to learn to enjoy the real comforts of life -- good food and drink (not expensive food and drink), music, books, the companionship of friends and family, etc.