I was thinking along the same lines, especially after reading
this link on Financial Samurai's blog yesterday. I admit, I went on to the slicedinvesting site to see what they offered, but finally convinced myself I was just being foolish trying to chase hedge fund money.
When I've thought about what could disrupt the buy/hold strategy, one thing that comes to mind is taking advantage of the automatic nature of investing these days. Between large endowments, big blocks of individuals all invested in just a few large mutual funds at Vanguard, Fidelity, etc., pension funds, and other institutional investors, I feel like the opportunity for some force to leverage these relatively passive and very large investors into situations that profit from the nature of these investors is getting easier. And not necessarily at the level of cleaning house and leaving the rest of us holding the bag, I'm thinking more along the lines of subtle movements, and changes that leech away small amounts of return. The idea that late IPOs might deprive the market of some of their "run-up" in value makes sense, but I agree that's likely small. But there are probably more serious and far-reaching ways in which this can affect us.
I'm in medicine, and in the US, the financial side of medicine is a mess, and it's only getting more complicated and more difficult to navigate. And you are already seeing ways in which both sides, the payers and the providers, can game the system to eek out a little win here or there, at the expense of the other side. While I know that the movement towards low cost mutual funds is not quite as dramatic as it seems if you hang around here or Bogleheads mostly, I just can't help but think that the financial system "Wall Street" isn't going to figure out some way(s) to get back those lost revenues. Nothing sinister, but where there is a combination of strong motivation ($$$) plus a relatively opaque and complex arrangement, human ingenuity finds a way.