Can you contribute to a Roth IRA with your income being so high?! I believe the max income limit is $196k for a Roth.
If you are self-employed with no employees you should look into a SEP-IRA. However, if your income is too high to contribute to a Roth, you would only be able to contribute to a traditional--and I don't believe you will be able to get the tax deduction that comes with a traditional IRA if you have any employer IRA plan (the SEP) and make over $99k.
Do you have a high deductible insurance plan with an HSA? You would be able to contribute $3500 a year each. An HSA is a triple tax benefit: contributions are tax free, medical expenses are tax free, and assets are tax free-- and if you don't use it, it becomes another IRA.
After all of these options have been maxed out, then the remainder should do into taxable accounts.