Hi there Piet. I'm (we) are in actually the same situation as you - Dutch mid-thirty couple, having mostly lived abroad during our working life, earning in other than EUR currencies we certainly face additional risks i.e. currency translation & and where exactly to RE.
The way we do it is by having several bank accounts, the most important one are ING/Binckbank in the Netherlands where the bulk of of our investments are located (ca. 65%). Other bankaccounts are in Switzerland, Brazil and our current domicile, a HCOL tax haven metropole in Asia - so there is essentially always a bankaccount nearby. As we travel a lot we find it very beneficial to have a diverse set of accounts (and also at almost zero costs).
What I would do in your case, (just imho) is to find a reliable bank with good online access. And not just online access, but essentially paperless. For us the reason why we stick with ING/Binck as about anything can be arranged online, or else by phone once set-up.
Depending where you want to RE (I guess you're too young still to be sure, same for us as well), I would adjust your stache in that location accordingly (for us, likely EU or Switzerland). I any case I would watch out with FI in a LCOL area, you really might limit yourself in terms of future moves to a HCOL area.
Remember that you might invest USD in ETFs or if you dare in individual stock, most of the companies are highly diversified themselves anyway due to their global business reach, so even if you invest USD returns might be based on EUR, for example.
Also, depending on your investing horizon, given your age I would 100% invest in equity ETF, but that's just me, as I believe that this would be long term the best pay off anyway, provided you can handle the volatility.