As a retired custom home builder, I don't want to offend you, but this whole idea is a vast waste of time, and money. First, as noted, if you are building a home, leave the herd mentality behind, and build what you NEED, not what society expect you to do, or what results in better resale. Single family homes are well documented money pits with horrendous returns, and there is no need to build a bigger one that you need. Second, study things like net-zero, and other techniques that can provide a home with very, very little energy usage. If you build a sophisticated machine to occupy, you have very little in the way of energy usage, and no need to be zoning areas off.
Finally, give a lot more thought to how impractical you whole idea is. Not only will you need to be able to mechanically seal the room's HVAC supply with a motorized damper (which are commonly available and used in commercial and institutional applications every day, BTW) you would need to damper individual returns in each room, as the returns could create convection currents if left open in a partially decommissioned system. Whole house HVAC systems are designed for.......... the whole house. Which leads to the fact that operating a system designed to heat and cool X amount of volume, while throttling it back to X-60%, will only result in inefficiency. The motorized sliders would also present a huge issue, as they would all need safety interlocks, in the same manner that garage doors do. The possibility of crushing children and pets in remotely operated doors is not something that most code inspectors would be willing to ignore, nor should you. Overall you are bringing a shotgun to a mosquito swatting contest.
This whole idea reminds me of a home one of my customers bought. The place was a very large 1980s colonial. The builder was very ahead of his time, and built an extraordinarily efficient building. He also did a one-off HVAC system that would of made a NASA engineer jealous. It had countless relays, dampers, fresh air intakes, controls, and other widgets. It worked great.........................until it didn't. Then the customer went through countless HVAC service contractors who would come, and stare at the massive three ring binder of system data and drawings, then attempt some type of futile fiddling to justify the service call. After a few years of this frustration, the owner had the entire system deposited in a dumpster and installed something that was reliable and simple. The annual cost of heating and cooling the home stayed the same.
As I sat in freshman Physics 101 on the very first day, the prof. wrote KIS on the board in big letters. He said, "that stands for Keep It Simple. The world of physics is hard enough without overthinking and overcomplicating things". It's a good lesson to learn.
EDIT: In 2013 I built a new home for my wife and I. It's 1200 sq. ft. Well insulated and detailed, and costs $5-600 a year to heat. Each room is heated by a slim, compact, modern version of the old standby electric baseboard unit, controlled by a digital thermostat. Unused rooms (typically a guest bedroom and a small office) are left at 50* in the winter, with the doors closed. I've build dozens of homes over the years and installed most commonly available HVAC systems, for my place I went with the KIS plan. Simple, cheap and trouble free. It would of run me $7-10K to install a well done HVAC system with a super efficient propane furnace and high SEER AC. My electric heat materials ran me a few hundred bucks, and two new window ACs (then run about ten days a summer here) brought the total to less than a grand. Given resale and payback calculations, the full HVAC system made no sense at all in this climate.
