As has been mentioned, more goes into a properly designed HVAC layout than just duct sizing. I don't recall all of the rules and calculations I looked up when making some changes to my HVAC (and I will probably look up again when I want to make more changes), but I do recall that most residential system I have seen are not correct; that is for a variety of reason, some were just rule of thumbed from the beginning, some had sloppy add ons, some had intentional compromises made.
A couple things.
you have 22 6 inch supplies? (how big is your house? I only have 10 in a 3,200 sq/ft house that needs 74,000 BTU of heating).
How big is the duct coming out of the air handler? If the main trunk is not 24"x24" (roughly the same cross section area as 22 6 inch ducts) then that is trunk is your smallest point. (unless you have the dreaded duct-o-pus). Those supplies may be larger to accommodate resistance encountered from turns (or because that was what the builder was used to working with).
Ductwork return sizing is based on CFM needs, which in turn is based on how much heating or cooling the system provides. You should be able to find out how much return register area you need if you know your heating/cooling. Then you can figure out the duct sizing needs based on run length and number of turns. If you have more supply ducts than returns, but enough return area, I doubt it will be a problem (the air will just be spread out).
If I recall correctly there is a test you can do to ensure your supply and return are balanced. It requires taking static pressures in the supply and return (this is the first google link that appears to be dealing with it:
https://www.primexvents.com/static-pressure-testing-hvac/). Basically too low a pressure on the return side and there is not enough return flow, too much pressure on the supply side and not enough supplies (I don't think you have to worry).