In general, you need the same size returns as the the amount of air supply going up. So if you have 3 6" round ducts, you need 3 6" round ducts return (or the equivalent size of air, so a big 10x8 rectangle, or 2 3.5"x 13.5"). In theory, you want your supply to terminate on the exterior of the building (normally under a window) and the returns high up on the wall near the ceiling in the center of the home with equal supply and return in each room. Optimally, you will have no ducting run along an exterior wall.
This may be very difficult for you to achieve. So, one big return in the hallway is ok, but you have to make sure you have an inch gap of space under each door to allow for air flow.
For returns now, they want you to hard pipe the entire run, where previously you could use an open chase between studs and drywall to act as your return. This may be easier for you to achieve especially if your home was balloon framed and does not have fire blocking.
Also, flex ducting doesn't allow for the same airflow as smooth pipe
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