First, do
not make any big life-changing decisions right now. You are going through a huge upheaval right now with the job loss, which means your head isn't in a good place to make long-term decisions.
Second: take stock of where you are. Are you eligible for unemployment? Can you get the "extra" Coronavirus unemployment? What are your monthly expenses? You want to figure out two things: (1) how long you can live on unemployment/other income sources without having to tap into your savings; and (2) how long you can make it without taking money from your 401(k). Depending on your lifestyle, that could be anywhere from a couple of months to forever.
I hope that seeing that number will give you a little relief by showing you you don't need a new job right away. You should then also look at what you can cut from your lifestyle to extend your money even longer. For this, you really need to do the full case study, laying out everything you spend. I have a hunch that you can't do that, though, because you don't have much of a clue what you spend -- right? So start tracking that. While you're at home, go through your CC statements and bank account and pull together what you've spent over the past couple of months to get an average. I guarantee you that the total will shock the hell out of you, because when you're not paying attention, you have no idea how fast all those restaurant meals and Target runs add up.
When you know what you need to support your lifestyle, then you are in a position to weigh all your options for employment. If you can support yourself for a year or more, then you can afford to hold out for another comparable position. OTOH, if you've got an expensive rental and an expensive car payment and fancy habits, then you're going to need to go get any job you can find to bring in cash.
FWIW, I agree with
@former player that you can spin your experience into a positive, or at least not a negative. You yourself said that it took 15-20 years to fully develop your current high-level qualifications. So why not explain that you were focused on doing that and so followed different opportunities that allowed you to continue to improve your skills and qualifications? But now that you have reached your goal, you'd really like to settle down and use those skills to build a career, etc.
But you do also need to do some work on yourself to figure out why you so enjoy flitting around from place to place and job to job, so that when you do get that next job, you are happy to stay there for a while. Because you are approaching the age where it
will get harder and harder to get that next job, and if you're not careful, you could end up in a place that you hate just because you don't have better options. Time to figure out what you need to make you happy in your chosen field for more than a couple of years. What about a consulting firm? If you like mixing things up with different issues and different people, then it seems to me you may be a better fit as a consultant than an employee.
BTW: going back to school is right out. You've just spent the better parts of two decades chasing your current qualifications. Starting all over again in another area is just another way to continue the chase. And a franchise? For someone to whom doing the same thing all day, every day, feels like death warmed over? Yeah, thanks, no. You enjoy your current area enough to have spent 20+ years in it. So figure out what you need to be happier for your remaining working years, but building onto what you've already achieved. The grass is rarely greener.
Good luck! Believe it or not, you are in a good position: you have cash to support yourself, and time to figure out what you need and want. Use it wisely.