You're single, or married, or married with kids?
If single, enjoy. I found it to get old awfully fast not remembering what time zone I was in when I woke up on not-my-bed. If you're married... eh. If you're married with kids in the house, seriously reconsider.
If you have a choice of airline, definitely pick one and stick with it - find out who has good perks. I don't fly enough to get myself into business class, so I typically go Southwest, but one of American or United is pretty good (the other crams you in like sardines in cattle class, and I don't recall which is which).
Get TSA Precheck - if you're in the US. It's a thing that absolutely shouldn't exist (being able to buy your way out of the pornoscopes and long lines), and it's a thing that's huge if you're flying a lot - you just go through a metal detector and don't have to strip down/unpack your laptops/etc.
Figure out a good backpack for the plane. I generally fly with core essentials in my backpack and check a bag, but I also fly Southwest so I don't have to pay to do that - and it's nice not having to wait for the "Ok, bins are full, we'll gate check for free..." games played on other airlines. I typically sit towards the rear, and have a post-flight routine that involves stretching and a nice luxurious bathroom break in a full sized stall, so I rarely find myself actually waiting for luggage.
Staying healthy is the biggest challenge, and I don't travel enough to really have good advice. I typically run to a grocery store and buy a couple things (fruits, veggies, granola bars, etc) when I land so I'm not tempted to hit restaurants as often. Some are nice, but it gets old in a hurry IMO.
And be prepared to pull the plug if you don't like it. I found heavy travel kind of novel for about 6 months, then just got tired of not being home.