definitely. Follow "The Points Guy" on facebook and check out the audio book by Brad Wilson from Brad's Deals ("Do More, Spend Less") Churning/travel hacking is fine as long as you don't mind taking temporary hits to your credit score. If you're going to buy a house or some other purchase, you want to do it very carefully to ensure you don't raise any red flags. My favorite strategy-- Open four of the same card; you (personal), you (business), your wife (personal), your wife (business). This could easily net you 160,000 to 200,000 points in a short period of time depending on your spending habits. If you're flying the right airlines, you can really get good values. For domestic travel, Chase Ultimate Rewards is good. consider a $200 domestic ticket; Chase gives you a 20% discount if you book through the ultimate rewards site. so it would only cost 16,000 points in contrast to the best saver fare on most airlines which would be 25,000 points.
So, you could sign up for the personal card (45,000 points with spousal card and $3000 spend in the first month + 1 spouse card transaction). Do the same with the business card. She does the same with both and you have 180,000 points or enough for ~11 round trip tickets (@$200 each) for a value of over $2000.