Well, you can check google maps for distances, but Holly Springs is pretty far out, IMHO. The new toll road (SW portion of 540) would make an airport trip about 30 minutes, if you don't mind the toll. Of course that's from "Holly Springs", not inside some development, which may add time as well.
Anything labeled 55, 54, US 1, I-40, Davis Dr (1613 on the map) will be busy (often stop and roll) during rush hour. The Beltline, US 70, 401, basically any major artery will be crowded. Google maps will show traffic - you just have to check then.
If you can find the shops and schools you like in Holly Springs, then great. Otherwise you'll be spending a lot of time on the road.