To me, the fact that both you and your wife are sick of the travel is determinative. A fat paycheck isn't worth it if it loses the things you are working for (relationship with your wife, family, etc.).
But that doesn't mean quit now -- it means get a firm handle on what you spend now, what you need to make, and what your options are. I second the notion to do a case study to give you some hard numbers -- if quitting is going to mean major tradeoffs, like selling the house or moving to a cheaper area, you want to know that before you make the decision.
Once you know how much you need, you can think more clearly about your options to get there. E.g., personally, I would not feel confident in something like Lyft to cover the load; $1500/week sounds extremely optimistic, and you don't want base your decision on optimistic projections and then find yourself working 14-hr days to make ends meet and not seeing your family anyway. Running your own school might work, but what's the business plan, what's the basis for the income projections, and how much are you going to need to cover out of pocket before you start making that income (and where is that cash going to come from?)? OTOH, maybe there are closer-to-home sales positions -- sure, they probably won't pay $150-200K (there's probably a reason you make that much now, a/k/a they are paying you a premium because the travel sucks), but if you only need, say, $30K or $50K, that opens up a whole new universe of jobs that can cover your bills and give you more of your life back. Heck, once you know how much less you need and have decided you're willing to leave to get it, you could even go back to your current employer and ask about alternatives with less travel, even if it means a paycut. Who knows, if they appreciate your skills, they might want to find a way to keep you around.
Tl;dr: you need to know what you need and what you have first. Then you can figure out how to fill the gap.
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