Some of this depends on what you spend on. For example, Chase Sapphire Reserve has 3x points on restaurant meals and travel spending, but the typical Mustachian may not spend much in those categories, making the hefty annual fee not worth it (although honestly, the way Chase points work, it may still be worth it). It also depends which airline you fly. I think the Southwest Plus is a screaming good deal at a $69 annual fee, 50k sign up bonus, and Southwest points tend to have a higher redemption value than other airline points, at least flying from my city.
Read a bit on the site linked and The Points Guy about how all this works, then decide on a card and just go with it.