My career (such as it is) has very much been driven by lifestyle over ambition. As I got older, money factored in a bit more, but never at the expense of work-life balance. And I've sometimes felt that I should find a more "meaningful" career, but ultimately (so far) I've found meaning in providing for my family and enabling us to have a lifestyle that works for us.
After college, I taught English overseas (Taiwan) for 5 years. This decision was entirely based on wanting to live in Taiwan (as opposed to a passion for teaching English). At the same time, I enjoyed the job, and I saved ~50% of my (relatively small) income. Then I got a Masters Degree (paid for by a teaching assistantship) and then I taught for a year in China (again, because I wanted to live in China). I then got a job at an American university, and transitioned into administration due to a combination of liking to do computer stuff (e.g. making a student records database) and departmental changes that brought about tremendous growth (250 students to 1200 students over a few years). During my 10 years there, I had 6 different titles and my salary doubled. At the same time, I did say "no" to a couple of positions due to work-life balance concerns.
And then, ~4 years ago, we decided we wanted to move to Canada. I found a job working with a company that worked very closely with my department which would also allow me work from Canada. It was a lateral move in terms of salary, but the work is very different (I'm now a business analyst) and, most importantly, it enables my family to live in a small town in Nova Scotia which we absolutely love. If I hadn't gotten this job, we likely would have settled in / close to Halifax (for work opportunities), and none of us prefer the city.
I sometimes think about changing jobs (seeking something "meaningful") but I like the people I work with and a lot of the logistical elements are very good -- I work from home, I don't work outside business hours, I get paid well (by my modest standards). I also sometimes think about changing jobs to meet more local people / be face to face, but the reality is that my skillset (while in demand) would likely work best as a consultant, and I'm not much of a hustler / networker, so I don't know how well I'd do with that. At the same time, I've started working with someone locally who does database development and other IT consulting so we'll see. I'm thinking that, in 2-3 years, I'd like to downshift (or quit) and these local opportunities could be a good hobby job.
I mostly feel tremendously grateful for having had jobs that have enabled me (and later us) to save money and live where I want, but I do sometimes wonder if I should be doing something "more". At the same time, I have no idea what that is -- I have no great professional passion. I like spending time with my family, hiking and meditating. Messing around on computers is OK, too, but significantly further down the list. And it's the only one I've been able to turn into a job so far. :)