In my experience, the only way to answer this question is to lay out your typical healthcare expenses, model a year under each plan option, and figure out which one has the lowest cost. For extra certainty, you could check a "worst likely case" (i.e. if you typically use very little care, assume you'll go to the emergency room, or have to get a few tests run at a specialist and start a prescription). With the HSA, this analysis should estimate the tax benefit of putting your pre-tax money in the account.
In my case, I'm pretty sure my employer structures the premium contributions to make it so the HSA always wins. They offer a PPO, but I can't come up with a scenario where it is appropriate for anyone (young, old, healthy or comatose), so rules of thumb like "young and healthy people should do an HSA" are not necessarily true. Doing the math is the only way to know.