While this Honda *can* go hundreds of thousands of miles, it's going to have stuff wear out along the way and if you're not a DIY person, you'll likely be making calculations about keep/sell when a couple big expense items come up. Off the top of my head from the many Hondas I've owned:
Alternators tend to go between 100k and 120k miles. (real pain to change)
Water pumps tend to go around 100k. If you replace with timing belt changes, you'll never see a failure.
Of course, brakes and tires are going to wear out.
Shocks wear out.
Belts/hoses age out.
Honda automatic transmissions can fail. Manuals seem to go forever.
CV boots go and you might as well replace the axles as an axle is typically cheaper than 2 boots.
For DIY people, none of these things are a big deal. I find it a game to find new and interesting ways to get an old alternator out of a Honda. The book will give me the choice of removing the brake booster or the lower control arm. I'll maze it out doing neither of these things, then declare victory and dance around the garage. Big parts are a dime a dozen used. Need a transmission, engine, control arms, engine mounts.....they're easy. Want to up your power with a different engine? Every possible swap has aftermarket mounts available for you to just order up. Even swapping from auto to manual or from hydraulic clutch to cable clutch is pretty common and parts are easy and cheap.
But like any car....if you're paying your mechanic $100 an hour for repairs, you'll likely unload the car long before it's done for.