In my experience, everything is relative -- the market demands what the market demands. But, I find that my dollars go way, way further in LCOL areas than high ones.
Completely anecdotal, but I know a married couple that live in Columbus, Ohio that make around $250k per year. They came to mind because they are similar to my family in that the husband is an attorney (like me) and the wife works in healthcare (like my wife). They just bought a 1,700 square foot colonial for $315,000, and it needed completely redone. I lived in Columbus for eight years and can also say that everything -- parking, restaurants, social stuff, real estate taxes, etc. -- are more expensive than where I live now.
I live in NE Ohio, and my wife and I earn about $160k per year. We just bought a 3,100 square foot colonial, completely updated and remodeled, for $285,000. People visiting back home from bigger cities think we are millionaires or something. In fact, a friend from Chicago stopped by over Memorial Day weekend and said our house would be $600,000 or more in the Chicago suburbs.
What salary makes up that difference? I'm not smart enough to figure that out. I just know that everything is relative.
So, I wouldn't get so tied up in the dollar amount. Look at real estate prices in the area. Check out menus (my friend from Chicago was also amazed that you could go out to eat, get an appetizer, entree, and two beers for $25). I think you'll be pleasantly surprised.
***
As to the above comment about FIRE, it's all relative there as well. Lower cost of living means a lower FIRE number.