My husband started traveling pretty much the day our first child was born and it's been hell. It has brought our marriage to the brink a few times, and I can honestly say, that is the only real issue we have, but it's a big one. As the "resident parent," I am responsible for the running of the household (which is a significant responsibility with three kids and three dogs) on top of having a relatively big job. For the first two-thirds of our marriage, I also out-earned him, and I can tell you, the resentment was significant because I was doing more of EVERYTHING. So please be aware of the extra strain this will place on your wife, and find ways to mitigate that as much as possible.
All that said, I think there are ways to make this work. A lot will depend on how on board your wife is (I was not, I had a dad who travelled all the time for work and I did NOT want that in a partner or the father of my children). Also, as others have mentioned, how flexible and demanding her job is, how willing you are to pick up slack when you are home to give your wife a break, how much you show her you appreciate the extra burden she's shouldering, how much you can be responsible for from the road (e.g., making doctor's appointments). And, my DH's travel has been for weeks, sometimes months, at a time, adding up to six months one year and nine months another (those were the two worst years).
I find 1-3 nights to be pretty manageable. After that, it gets hard. And if it was week after week, it might get tiresome for both of you. Are you open to hiring more help if need be? To her going part-time if it's too much? To finding a new job if it just doesn't work for the family?