There are duct cleaning scams out there for sure. If you decide to do it, be sure the company actually uses specialized vacuums and sends them all through your ducts to get the gunk out. Some companies just dust the grilles off and wipe out the boots and charge you big money.
A lot of people think they need duct cleaning when they don't. Most of the dust inside your ducts isn't getting into your home. I think the EPA has some literature on this, so you might want to look it up. That said, this house was built in the 40s and maybe had central AC installed when? The 60s or 70s? Regardless, you don't know who has lived there, how often they smoked inside, or whether they had pets. So, yeah. I'd get the ducts cleaned in your case.
We had ours cleaned. They brought out the giant vacuums and everything. My place had been a rental before we bought it, and I'm pretty sure the tenants weren't changing the air filters on a regular basis or even using them at all. The return duct was revolting. I also had it on good authority that previous tenants had dogs, so there's that. Animals will really nasty up your air.