No, no. Everyone else here is wrong.
If you fly you'll miss out on: the meth heads on the road in St. Louis (70% of them), the insomnia inducing cornfields of Illinois and Indiana, broken up by an occasional suicidal deer that wants nothing more than to jump through your windshield and bleed out in your lap. Then, there's Ohio. Fucking Ohio. Full to the fucking brim with Ohioans. Where everyone drives 52 mph in the left lane. But, wait, you'll also miss out on the spooky parts of West Virginia. Deliverance country. Depending on your route, you can enjoy the PA Turnpike, where the lanes are three feet wide, there is no shoulder, just a immovable concrete barrier separating you from every pill popping trucker in the oncoming lane, except for the pill popping trucker behind you that will not use his brakes no matter how GD close he may come to you at the very nadir of Mt. Pennsyltucky. And then, you'll hit the DC metro traffic, which begins about 200 miles out and will come to a complete fucking standstill for hours if a butterfly flaps its wings too close the road. Aaaaa! AAaaagaghhhg! AAAAAAAAAAAAAAGH!
And once you're done with DC, you get to turn around and do it all again.
Yes, you should totally drive.