Lossless (or uncompressed) video tends to be large and impractical (35-40GB/hr for standard definition like VHS). If that's what you really want though, it can be done. What you're probably looking for is some sort of PCI/USB capture card and simple software to tap into that and dump the stream (VLC should do the job). I haven't messed with lossless video in a long time, but huffyuv was popular in the past.
Given the analog nature of the source, I'd focus on getting the highest quality signal *to* the computer. You'll want to track down the best VCR you can get. That'll probably end up being a JVC SVHS VCR, but I don't know much beyond that. For extra capture quality too, you could try to find some capture card with the best comb filter, but I don't know how nuts you want to go with quality (but I also have no idea if that's still an issue). You could also do multiple captures and combine them for best accuracy TooT style and do extra post-processing like stabilization.