Have you done the research to see if the job market for whatever field you're applying for is good in that area? There may be a glut of people that are there already applying for those same jobs, so that is going to put you at a disadvantage. Are you willing to take jobs in other related fields (advertising copywriter, teacher, etc) so that you could move to the area? Unless you've got some stellar work to show off, I'm not sure that most places would consider hiring someone sight unseen for a university administrative position unless you're a shooting star... most colleges I've been familiar with are a very insulated group and they tend to hire from within their own ranks.
What about your wife's job prospects? Is she going to be able to find something pretty easily?
Have someone knowledgeable vet your resume, and do some networking through sites like LinkedIn.
If it was me, I'd probably save up a good chunk of money and head up there to do a few weeks of pounding the pavement for some actual face time and see if I could squeeze in some interviews. If you were single, I'd say just move up there and stay with your brother (if he is cool with you staying for a few months) and work wherever you could find employment until you landed a job in your field, but with a wife and child also to think of, not sure I'd jump straight to that with that kind of responsibility (but depending on the job market and how much you have for savings, it's still a possible if you're fully committed to moving to that area).