You want to use those Vanguard funds in your 401k to construct a portfolio that meets your desired asset allocation, aka what percentage in stocks and what percentage in bonds. You didn't say what you feel comfortable with (besides "more aggressive), so it's hard to give specific advice. But if I was you, I would do something like...
50% - Vanguard S&P 500
20% - Vanguard Small Cap
10% - Vanguard Developed Markets
20% - Vanguard Total Bond Market
Again, that's just sort of a general, heavy U.S. equities but otherwise market weighted portfolio. In the end the actual AA likely won't matter as much as long as you find something you are comfortable with even if the market were to tank. The higher the percentage of equities, the more your portfolio value can drop. If you will ride out those storms, then it's ok to be riskier (more stocks and less bonds).
I strongly encourage you to do more research on developing a personal AA. I recommend starting here:
http://www.bogleheads.org/wiki/Asset_allocation