Hmm. This one is tough. My disclaimer--I'm not a good mustachian but I'm pretty god at career advice. Some tough love-- you shouldn't take yourself out of the running for a job until you have an offer. Otherwise you don't know what you're comparing. You can usually negotiate salary, benefits, and office space. You can also find out more about office culture and reorganization when an offer is on the table.
That said, since you already sent the email, my suggestion would be to send an email to the hiring manager, say you saw the position was reposted, and ask to have coffee or lunch to chat. Then you could talk casually about your concerns and see if they can be addressed. If it sounds promising, reapply. If not, you made a connection and a friend.
This could also be an opportunity to talk to your current office about your concerns. Just talk to them about your interests and if they'd help you develop them. Ask about succession planning. It can't hurt!