Depends on where you're going from. We're in Oregon, so Hawaii was a great cheap option. Sign up for Scott's Cheap flights and watch for deals to come up! We opted for an AirBnB and renting a car through Turo. We did 10 days in Maui and spent tons on food and booze, no flight points at all, and spend $3200. But if you're going from the East Coast, there are different answers there.
Also depends if you're planning on trying for kids soon, in which case, being aware of active, inactive, and zika free zones is a good idea!