I travel and move every 6-9 months. For the past 4 years it's been all studios. At first it was a bit of an adjustment, but not too much of a lifestyle cramp. I just moved into a very LCOL area for rent and decided to splurge on a small one-bed. I hate the extra space! It feels like I don't have enough stuff, I can't fall asleep in the same room as the chair I read in and wake up a step away from bed, or the bathroom, or the kitchen. The bedroom is always hotter than the living room, yuk. Too much work! It's stressing me out! :)
Bottom line, I think you like what you get used too. For me, 300-450sq feet and no bedroom is about right.