Interesting discussion all around.
As disclosure, I am an M.D. with a lot of free time, access to a lab with blood tests including all the expensive send outs available to us in the US. My main interests are lifestyle optimization and self-experimentation.
My general conclusion is, the optimal diet for humans is PROBABLY one that is heavily plant-derived, on the order of 95-98% of meals. It should include some fish and probably eggs.
The 100% plant based, vegan diet is too tricky. The omega 6:omega 3 ratio is too high. You need the marine DHA and EPA for optimal eye, brain, and cardiovascular function. Even if you wanted to supplement with vegan omega 3s (assuming pills are as effective as eating food, which I am not sure is true), you would have to take 9-12 capsules of Algae based omega 3s per day to get enough of the quantity shown to have a beneficial effect.
Eggs, only recently we are discovering have so many obscure nutrients that are very beneficial, in both the yolk and white. Alas, they are not vegan.
My biggest problem with the vegan diet is : I spent 3-4X of my typical time thinking about, sourcing, preparing, and eating food. This is time that could be used to save human lives, build a business, philanthropy, humanitarian work etc. So when I do my 6 week or 3 month experiments eating 100% plant based, I feel SELFISH, like I am focusing on myself too much. I think this is parodoxical to the intent of the diet, but there it is.
People who believe they got this benefit going on a vegan (or other) diet, in my experience did so because they cut processed food from their diet. Most tempting things we see on the shelves and at Starbucks (cakes, cookies, brownies, etc) are NOT vegan, so people end up eating less processed food.
For those who haven't already, I recommend reading the book "Bad Science". This is one of the few 'must reads' I would recommend across the board.