Since I already have plans and am somewhere between able to semi-retire and a few years away from not expecting to need income ever again, I know where my next $250k is going, and it would be a delight to get it all at once.
Although I'd probably be miffed at whoever had that much dough and was hiding that from me, not because they owed it to me, but all the people I could think of that I might inherit from have places that money needs to go for them or their obligations.
But since I have a plan, the default is now 80% broad stock fund with low ER, probably ETF, and 20% U.S. bond index, again low ER, probably ETF. But probably minus some cash to bring me up to two years' expenses as with a sudden extra $250k I'd have well more than one foot out the door of full-time work.
I've only recently gone to 80/20 from 60/40 after getting the exact benefits coming from my pension, estimates from SS, and their being close enough that I have more confidence they'll still be there when I reach them. The annuitized income will keep me above poverty level by itself which makes portfolio survivability much less worrisome, so I'm upping the risk. Up until quite recently my favorite vehicle was VG Wellington, and I still have substantial monies there, in fact I haven't got rid of any. But in other places I got out of copycat balanced funds and into cheap index funds and skewed the balance close to 80% stocks overall, but I'm counting cash along with my bonds as the other 20% when setting AA for now.
(I'm not the pay-off-the-mortgage type.)