Colorado vehicle registration includes "OWN TAX" (ownership tax) on the value of the vehicle. If you itemize deductions, this portion is deducible.
The passenger vehicle & light truck tax is based on the original sales price of the vehicle, and starts at 2.1% for the first year, declining to 0.45% for years 6 - 9. For years 10 and beyond the OWN TAX is $3/yr.
Additionally, there are flat fees, currently totally about $100.
There will also be biannual emissions test for about $25. When registering a vehicle for the first time in Colorado, you may also need a VIN Verification Certificate for about $20.
As background, Colorado finances road construction through license/registration fees, gas tax, and some general tax funds. The TABOR law (TAxpayer's Bill Of Rights) has limited the ability of government to raise taxes rates (and net tax collections), such as the tax on value of a vehicle, but road & bridge fees (assessed regardless of value) were found by the courts not to be taxes. The fees increased substantially about 5 years ago.
Just remember Colorado is a fairly low tax state. My property taxes in Denver city limits are about 0.52% of market value of my home. Most people on the coasts will love our property tax rates.