Like the post by Tom Bri below, I grew up in a very rural area, moved to a town of 25k for college, and then made the move to Des Moines, which has an approximate population of 600k, including the metro area. I did that for 5 years, and have never been happier since we moved BACK to our rural area. First, to an acreage that was 3.35 acres, with enough lawn to keep me mowing for 2.5-3 hours, depending on how nice I wanted it to look. From there, we moved back to my home town, which has a staggering population for 400, including 0 convenience stores, 0 clinics, 0 stop lights, and 0 chain-anythings.
It's glorious, but I understand that everyone has their own mindset. For me, if I got stuck in a hipster city, I'd probably have a nervous breakdown.
Now, we do have quite a bit of things to do in our area, if you like county fairs, livestock, and country concerts. It's about 45 minutes to the nearest Walmart, and 25 minutes to the nearest stop light, McDonald's, and hospital. I couldn't ask for anything better, it just fits us.