I've never heard of any rule of thumb. I think you just have to run your numbers, keeping in mind that the new tax law has just dramatically changed the likelihood of itemizing for many people.
So, if you ARE itemizing, and you take out a 600K 30 year mortgage (750K - 20% down), at about 4.something % rate, then your interest will run approx 20-25K per year for the first few years, plus e.g. 12K prop tax = ~35K deductible x .30 tax bracket = ~10.5K saved on taxes.
Someone will surely be along to correct my numbers if they are wrong.