So this is a single family home in Denver? Would you live in it and have roommates pay your rent per room, or would you rent it out to a single tenant?
How much down payment will you be able to bring to the table?
All that impacts whether or not it's worth it. It probably won't be worth it as a rental to a single tenant, but could very well be worth it if you live in one room and rent out the other three.
For example: 10% down = $50k
Mortgage of $450k, 4.5%, 30 years, P&I is $2280.
Add taxes: $5k per year?
Add insurance: $2k per year?
Add PMI assuming only 10% down: $1500 per year?
Total payment before utilities and maintenance is approximately: $3000 per month (probably an overestimate, but it's best to do that)
Maintenance should be budgeted around 1% of property value per year, so call it about $3400/month inclusive of maintenance.
If you lived in one unit and rented out the other 3 bedrooms for $1200/month each, you'd have no housing expense yourself. But, that's highly unlikely unless the house is in ridiculously awesome shape and huge, but the price tag doesn't indicate that.
You'd more likely get $800/room or less leaving you with about $1k a month or more for you to cover, and all roommates split utilities.
Should you want to rent it out you'd probably want to add an expected vacancy loss of of month per year to that $3400 total payment, so you're probably needing to rent it out for at the very least $4k per month, but closer to $5k to actually make money as an investment.